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Correspondence
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Volume 336:222-224 January 16, 1997 Number 3
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Prosthetic Heart Valves

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 by Vongpatanasin, W.
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To the Editor: In their review of prosthetic heart valves, Vongpatanasin et al. (Aug. 8 issue)1 propose guidelines for anticoagulant therapy after valve implantation without citing references to support them. The authors make the surprising recommendation that patients with mechanical valves receive anticoagulant therapy "preferably within 6 to 12 hours" after valve implantation. If this recommendation refers to warfarin, how is it administered? If it refers to heparin, then the patient is at risk for bleeding during this period, given the fact that platelets are nonfunctioning after weaning from cardiopulmonary bypass. It is unclear how best to deal with the . . . [Full Text of this Article]

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