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Previous Volume 336:232-233 January 16, 1997 Number 3

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(Oxford Monographs on Medical Genetics. No. 29.) Second edition. By R.J. McKinlay Gardner and Grant R. Sutherland. 478 pp., illustrated. New York, Oxford University Press, 1996. $59.50. ISBN 0-19-510615-6.

As one who has watched human cytogenetics from its birth in 1956 to its present extraordinary capabilities and who counsels families with chromosomal problems without ever having learned how to prepare a karyotype, I found this book a godsend. Human cytogenetics has progressed from simple counting to the identification of specific chromosome regions by banding to the use of fluorescent in situ hybridization, which identifies specific misplaced chromosomal material, and even the presence or absence of specific genes, by lighting up the chromosomes in various colors.

A major task for those who counsel families with genetic problems is to estimate . . . [Full Text of this Article]

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