Chronic viral hepatitis is the principal cause of chronic liverdisease, cirrhosis, and hepatocellular carcinoma in the worldand now ranks as the chief reason for liver transplantationin adults.1,2,3 Of the five known hepatitis viruses, three cancause persistent infection and chronic hepatitis: the hepatitisB virus (HBV),4 the hepatitis C virus (HCV),5 and the hepatitisdelta (or hepatitis D) virus (HDV).6 The other two viruses,hepatitis A and hepatitis E, cause acute, self-limited diseaseonly. Recent findings suggest that there is an additional formof viral hepatitis to which two recently discovered human viruses— the hepatitis G . . . [Full Text of this Article]
Chronic Hepatitis B
Clinical and Serologic Features
Therapy with Interferon Alfa
Indications for Therapy
Predictors of a Response to Therapy
Treatment of Patients with Atypical Forms of Hepatitis B
New Therapies for Hepatitis B
Chronic Delta Hepatitis
Clinical and Serologic Features
Therapy with Interferon Alfa
Chronic Hepatitis C
Clinical and Serologic Features
Therapy with Interferon Alfa
Indications for Therapy
Improving the Response Rate
Predictors of a Response to Therapy
Therapy for Atypical Forms of Chronic Hepatitis C
New Approaches to Therapy
Conclusions
Source Information
From the Liver Diseases Section, Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Md. (J.H.H.); and the Department of Internal Medicine, St. Louis University School of Medicine, St. Louis (A.M.D.).
Address reprint requests to Dr. Hoofnagle at Bldg. 31, Rm. 9A23, National Institutes of Health, Bethesda, MD 20892.
References
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