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Volume 336:377-379 January 30, 1997 Number 5
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Liver Disease in Pregnancy

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by Knox, T. A.
To the Editor: We were surprised to find that the review of liver disease in pregnancy (Aug. 22 issue)1 did not mention the recognized association between acute fatty liver of pregnancy and long-chain-3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency,2,3,4,5 a disorder of mitochondrial fatty-acid oxidation. This association opens a new chapter in our understanding of the pathogenesis of diseases of pregnancy related to metabolic disorders. For example, the accumulation of phenylalanine in a mother with phenylketonuria can have a teratogenic effect on an unaffected fetus.

A woman who is heterozygous for LCHAD deficiency and whose fetus has the disorder can have unexpected and . . . [Full Text of this Article]

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