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Previous Volume 336:434-436 February 6, 1997 Number 6 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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For approximately 30 years, hematologists have sought the humoral regulator of platelet production, thrombopoietin.¹ Although a factor with the appropriate physiologic effects was partially purified, the goal continued to evade researchers until 1994, when three laboratories simultaneously reported that c-Mpl ligand had the characteristics of thrombopoietin.² Synonyms for thrombopoietin in the literature are c-Mpl ligand, mpl ligand, megapoietin, and megakaryocyte growth and development factor (a truncated version of thrombopoietin).

What explains the fact that thrombopoietin was ultimately purified and characterized by five laboratories almost simultaneously? In 1992, Wendling and colleagues described the c-mpl gene, the cellular homologue of v-. . . [Full Text of this Article]

References

This article has been cited by other articles:

• Goulis, J, Chau, T N, Jordan, S, Mehta, A B, Watkinson, A, Rolles, K, Burroughs, A K (1999). Thrombopoietin concentrations are low in patients with cirrhosis and thrombocytopenia and are restored after orthotopic liver transplantation. Gut 44: 754-758 [Abstract] [Full Text]  
• Kaplan, A., Kaplan, S., Marcoe, K. F., Sauvage, L. R., Hammond, W. P. (1998). The Effect of Hematopoietic Growth Factors on Platelet Aggregability. CLIN APPL THROMB HEMOST 4: 238-242 [Abstract]  
• Baker, G. R., Levin, J. (1998). Transient Thrombocytopenia Produced by Administration of Macrophage Colony-Stimulating Factor: Investigations of the Mechanism. Blood 91: 89-99 [Abstract] [Full Text]