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Previous Volume 336:441-442 February 6, 1997 Number 6 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Hylek et al. (Aug. 22 issue)¹ imply that the lowest effective intensity of anticoagulation for patients with nonvalvular atrial fibrillation is an international normalized ratio (INR) >2.0. Although this intensity may be optimal to prevent ischemic stroke, it would be useful to establish whether an INR of 1.6 to 1.9 offers substantial protection, a point that is potentially important for patients at particular risk of bleeding during anticoagulant therapy.² If I interpret their data correctly, an INR of 1.6 to 1.9 was associated with a reduction of 75 percent or more in the risk of stroke, as . . . [Full Text of this Article]

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