Cerebral Microsporidiosis Due to Encephalitozoon cuniculi in a Patient with Human Immunodeficiency Virus Infection
Rainer Weber, M.D., Peter Deplazes, V.M.D., Markus Flepp, M.D., Alexander Mathis, Ph.D., Reinhard Baumann, M.D., Bärbel Sauer, Herbert Kuster, and Ruedi Lüthy, M.D.
Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.
Microsporidia are obligate, intracellular, spore-forming protozoathat are parasitic in every major animal group.1 Cerebral microsporidialinfection was first described in 1922 in rabbits with granulomatousencephalitis,2 and the organism was named Encephalitozoon cuniculi.3In 1959 and 1984, two cases of infection in children with seizuredisorders were attributed to E. cuniculi.4,5 The diagnosis wasbased on light-microscopical detection of microsporidial sporesin cerebrospinal fluid and urine samples, but the identificationof the species remained inconclusive, because immunologic andmolecular techniques to distinguish among encephalitozoon-likemicrosporidia were not available at that time. In recent years,three distinct encephalitozoon species (. . . [Full Text of this Article]
Case Report
Results
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From the Division of Infectious Diseases and Hospital Epidemiology, Department of Medicine, University Hospital (R.W., M.F., B.S., H.K., R.L.); the Institute of Parasitology, University of Zurich (P.D., A.M.); and the Anker-Huus, Diakoniewerk Bethanien (R.B.) — all in Zurich, Switzerland.
Address reprint requests to Dr. Weber at the Division of Infectious Diseases and Hospital Epidemiology, University Hospital, CH-8091 Zurich, Switzerland.
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A correction has been published: N Engl J Med 1997;337(9):640.
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