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Original Article
Brief Report
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Volume 336:547-550 February 20, 1997 Number 8
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Life-Threatening Cache Valley Virus Infection
Daniel J. Sexton, M.D., Pierre E. Rollin, M.D., Edward B. Breitschwerdt, D.V.M., G. Ralph Corey, M.D., Sarah A. Myers, M.D., Mark R. Dumais, M.D., Michael D. Bowen, Ph.D., Cynthia S. Goldsmith, M.G.S., Sherif R. Zaki, M.D., Ph.D., Stuart T. Nichol, Ph.D., Clarence J. Peters, M.D., and Thomas G. Ksiazek, D.V.M., Ph.D.

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The Bunyamwera serogroup (family Bunyaviridae, genus bunyavirus) contains more than 20 serologically cross-reactive viruses, 7 of which have been isolated in North America.1 Cache Valley virus, first isolated in Utah in 1956,2 has been recovered mainly from mosquitoes (genera culiseta, aedes, and anopheles) and occasionally from vertebrates and has the widest apparent distribution among this serogroup of viruses. Antibodies against Cache Valley virus and other viruses of the Bunyamwera serogroup are prevalent in livestock, large wild mammals, and humans from Alaska to Argentina.3 An association between Cache Valley virus infections and congenital malformations (various musculoskeletal and central nervous system defects) . . . [Full Text of this Article]

Case Report

Results

Pathological Analysis

Isolation of Virus

Discussion


Source Information

From the Department of Medicine, Division of Infectious Diseases, Duke University Medical Center, Durham, N.C. (D.J.S., G.R.C., S.A.M., M.R.D.); the Special Pathogens Branch (P.E.R., M.D.B., S.T.N., C.J.P., T.G.K.) and Molecular Pathology and Ultrastructural Activity (C.S.G., S.R.Z.), Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta; and the Intracellular Pathogens Laboratory, College of Veterinary Medicine, North Carolina State University, Raleigh (E.B.B.).

Address reprint requests to Dr. Rollin at the Special Pathogens Branch, MS G-14, Centers for Disease Control and Prevention, Atlanta, GA 30333.

References


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