FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 336:558-566 February 20, 1997 Number 8 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Paget's disease of bone is a localized, monostotic or polyostotic disease characterized by increased bone remodeling, bone hypertrophy, and abnormal bone structure that leads in symptomatic patients to pain and bone deformity. Complications involve the bones (fractures and neoplastic degeneration), joints (osteoarthritis), and nervous system. The short-term objective of treatment is to alleviate bone pain, and the long-term objective is to minimize or prevent the progression of the disease.

Pathology, Epidemiology, and Etiology

Pagetic bone is characterized by major disorganization in both the architecture and the lamellar texture of bone. These abnormalities are the results of major disturbances in bone remodeling (Figure 1A. . . [Full Text of this Article]

Clinical Features and Complications

Diagnosis

Drug Therapy

Calcitonin

Plicamycin and Gallium Nitrate

Bisphosphonates

            Common Properties

            Etidronate

            Pamidronate

            Alendronate

            Clodronate

            Tiludronate

            Other Bisphosphonates

Surgery in Patients with Paget's Disease

Recommendations

Indications for Therapy

Selection of Therapy

Follow-Up

Conclusions

Source Information

From the Department of Rheumatology and Bone Diseases and INSERM Unité 403, Hôpital Edouard Herriot, Lyons, France.

Address reprint requests to Dr. Delmas at INSERM Unité 403, Pavillon F, Hôpital Edouard Herriot, Place d'Arsonval, 69437 Lyons, CEDEX 03, France.

References

This article has been cited by other articles:

• Calif, E., Vlodavsky, E., Stahl, S. (2007). Ivory Fingers: Monostotic Paget's Disease of the Phalanges. J. Clin. Endocrinol. Metab. 92: 1590-1591 [Full Text]  
• Russell, R. G. G. (2007). Bisphosphonates: Mode of Action and Pharmacology. Pediatrics 119: S150-S162 [Abstract] [Full Text]  
• Klein, G. R., Parvizi, J. (2006). Surgical Manifestations of Paget's Disease.. J Am Acad Orthop Surg 14: 577-586 [Abstract] [Full Text]  
• Wu, B.-T., Su, Y.-H., Tsai, M.-T., Wasserman, S. M., Topper, J. N., Yang, R.-B. (2004). A Novel Secreted, Cell-surface Glycoprotein Containing Multiple Epidermal Growth Factor-like Repeats and One CUB Domain Is Highly Expressed in Primary Osteoblasts and Bones. J. Biol. Chem. 279: 37485-37490 [Abstract] [Full Text]  
• Langston, A. L., Ralston, S. H. (2004). Management of Paget's disease of bone. Rheumatology (Oxford) 43: 955-959 [Abstract] [Full Text]  
• Alvarez, L., Peris, P., Guanabens, N., Vidal, S., Quinto, Ll., Monegal, A., Pons, F., Ballesta, A. M., Munoz-Gomez, J. (2004). Long-term biochemical response after bisphosphonate therapy in Paget's disease of bone. Proposed intervals for monitoring treatment. Rheumatology (Oxford) 43: 869-874 [Abstract] [Full Text]  
• Donath, J., Krasznai, M., Fornet, B., Gergely, P. Jr., Poor, G. (2004). Effect of bisphosphonate treatment in patients with Paget's disease of the skull. Rheumatology (Oxford) 43: 89-94 [Abstract] [Full Text]  
• Parvizi, J., Frankle, M. A., Tiegs, R. D., Sim, F. H. (2003). Corrective Osteotomy for Deformity in Paget Disease. JBJS 85: 697-702 [Abstract] [Full Text]  
• Smith, S. E., Murphey, M. D., Motamedi, K., Mulligan, M. E., Resnik, C. S., Gannon, F. H. (2002). From the Archives of the AFIP: Radiologic Spectrum of Paget Disease of Bone and Its Complications with Pathologic Correlation. RadioGraphics 22: 1191-1216 [Abstract] [Full Text]  
• Pazianas, M., Zaidi, M., Schmaldienst, S., Dittrich, E., Watschinger, B., Pietschmann, P. (2002). Two underlying diseases causing hypercalcaemia?. Nephrol Dial Transplant 17: 1141-1141 [Full Text]  
• Schmaldienst, S., Dittrich, E., Pietschmann, P., Niederle, B., Becherer, A., Watschinger, B. (2001). A patient with evidence of two underlying diseases causing hypercalcaemia. Nephrol Dial Transplant 16: 2423-2425 [Full Text]  
• Nabili, V., Buckner, A. D., Niparko, J. K. (2001). Radiology Quiz Case. Arch Otolaryngol Head Neck Surg 127: 1137-1139 [Full Text]  
• Miller, N. R., McCarthy, E. F., Carter, N., Tamargo, R. J., Green, W. R. (1999). Lytic Paget Disease as a Cause of Orbital Cholesterol Granuloma. Arch Ophthalmol 117: 1084-1086 [Abstract] [Full Text]