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Correspondence
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Volume 336:586-587 February 20, 1997 Number 8
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Prophylaxis against Venous Thromboembolism after Major Trauma

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 by Geerts, W. H.
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To the Editor: We view with concern the claim of Geerts et al. (Sept. 5 issue)1 that the potent anticoagulant low-molecular-weight heparin can safely be used as routine prophylaxis against deep venous thrombosis in trauma victims. The study compared low-dose heparin with low-molecular-weight heparin in a cohort of 265 patients. The authors found that deep venous thrombosis occurred at a higher rate in the low-dose–heparin group (60 of 136 patients, or 44 percent) than in the low-molecular-weight–heparin group (40 of 129, or 31 percent; P = 0.014). Thus, 18 (60 minus 31 percent of 136) cases of deep venous thrombosis . . . [Full Text of this Article]

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