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Correspondence
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Volume 337:50-51 July 3, 1997 Number 1
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Residual Clones in Childhood Leukemia

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 by Roberts, W. M.
To the Editor: Roberts and his colleagues (Jan. 30 issue)1 do not emphasize that childhood acute lymphoblastic leukemia (ALL) is a heterogeneous disease with different rates of elimination of blast cells. The kinetics of the decrease in the minimal residual disease and the level of minimal residual disease that is compatible with a cure may differ among the leukemias and among the cytogenetic or immunophenotypic subtypes of childhood ALL.

For example, of six patients with a first complete remission of t(1;19)-positive ALL, five had molecular remissions within 3 months, and one had minimal residual disease after 84 months of complete . . . [Full Text of this Article]

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