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Previous Volume 337:710 September 4, 1997 Number 10 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Bernard, G. R. Related Article by Bernard, G. R. PubMed Citation

To the Editor: Bernard et al. (March 27 issue)¹ report the results of a double-blind, randomized, placebo-controlled study of intravenous ibuprofen in patients with sepsis. They conclude that treatment with ibuprofen is safe in these patients and has a favorable effect on fever, tachycardia, oxygen consumption, and lactic acidosis, but not on mortality. We are concerned about this report and its conclusions.

There is abundant evidence that arachidonic acid metabolites act as endogenous regulators of cytokine production.² Prostaglandin E₂ inhibits the release of interleukin-1 and tumor necrosis factor (TNF-).³ We tested the effect of ibuprofen on serum levels of . . . [Full Text of this Article]

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