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Previous Volume 337:794-795 September 11, 1997 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The diagnosis of a new Lyme disease infection by conventional assays may be difficult in persons who have antibodies to or immunologic memory of Borrelia burgdorferi proteins. This was the case in a recipient of vaccine containing recombinant outer-surface protein A (OspA) of B. burgdorferi (Connaught).¹ Analysis of the antibody and antigen constituents of B. burgdorferi–specific immune complexes can distinguish between past and active infection in such patients.^2,3

Several years before vaccination, a woman with Lyme disease documented by the presence of erythema migrans and by a positive polymerase-chain-reaction assay of a skin-biopsy specimen was successfully . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Wieneke, C. A., Lovrich, S. D., Callister, S. M., Jobe, D. A., Marks, J. A., Schell, R. F. (2000). Evaluation of Whole-Cell and OspC Enzyme-Linked Immunosorbent Assays for Discrimination of Early Lyme Borreliosis from OspA Vaccination. J. Clin. Microbiol. 38: 313-317 [Abstract] [Full Text]  
• Schutzer, S. E., Coyle, P. K., Reid, P., Holland, B. (1999). Borrelia burgdorferi-Specific Immune Complexes in Acute Lyme Disease. JAMA 282: 1942-1946 [Abstract] [Full Text]  
• Jensen, J. R., Du Chateau, B. K., Munson, E. L., Callister, S. M., Schell, R. F. (1998). Inhibition of the Production of Anti-OspA Borreliacidal Antibody with T Cells from Hamsters Vaccinated against Borrelia burgdorferi. Infect. Immun. 66: 1507-1512 [Abstract] [Full Text]