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Previous Volume 337:851-852 September 18, 1997 Number 12 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Although medications have dramatically improved the lives of many people with schizophrenia, treatment resistance remains a serious problem. Three quarters of patients with schizophrenia become ill before the age of 25. The manifestations of the disease include two types of symptoms — "positive" and "negative." Positive symptoms are distortions of normal functioning. Distortion of perceptions may appear as hallucinations; distortion of inferential thinking may lead to delusions. Negative symptoms involve the loss of normal functioning — the loss of will, range of affect, pleasure, and fluency and content of speech. The intensity of these symptoms and the residual disability they . . . [Full Text of this Article]

References

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• Chiles, J. A., Miller, A. L., Crismon, M. L., Rush, A. J., Krasnoff, A. S., Shon, S. S. (1999). The Texas Medication Algorithm Project: Development and Implementation of the Schizophrenia Algorithm. Psychiatr. Serv. 50: 69-74 [Abstract] [Full Text]