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Previous Volume 337:1003-1005 October 2, 1997 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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One of the great challenges in medical research is to conduct clinical trials in developing countries that will lead to therapies that benefit the citizens of these countries. Features of many developing countries — poverty, endemic diseases, and a low level of investment in health care systems — affect both the ease of performing trials and the selection of trials that can benefit the populations of the countries. Trials that make use of impoverished populations to test drugs for use solely in developed countries violate our most basic understanding of ethical behavior. Trials that apply scientific knowledge to interventions that . . . [Full Text of this Article]

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Ethics of Placebo-Controlled Trials of Zidovudine to Prevent the Perinatal Transmission of HIV in the Third World
Merson M. H., Simonds R.J., Rogers M. F., Dondero T. J., Francis D. P., Mbidde E. K., Blanche S., Kim R. J., Sharif S. K., Tafesse E., Murphy T. F., IJsselmuiden C. B., Herrington D., Piot P., Glantz L. H., Grodin M. A., Lallemant M., McIntosh K., Jourdain G., Le Coeur S., Vithayasai V., Lee T.-H., Hammer S., Prescott N., Essex M., Lurie P., Wolfe S. M.
Extract | Full Text  
N Engl J Med 1998; 338:836-841, Mar 19, 1998. Correspondence

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