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Previous Volume 337:1011-1013 October 2, 1997 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Splawski et al. (May 29 issue)¹ and others² have shown at the molecular level that the Jervell and Lange–Nielsen syndrome (prolonged QT interval on the electrocardiogram, associated with profound congenital deafness) may be caused by a homozygous mutation in the KVLQT1 gene, confirming that the Jervell and Lange–Nielsen syndrome and the Romano–Ward syndrome are allelic. Genetic heterogeneity has previously been demonstrated in the Romano–Ward syndrome, in that a heterozygous mutation in any of three genes, KVLQT1 (at the LQT1 locus), HERG (at the LQT2 locus), and SCN5A (at the LQT3 locus), and another as yet unidentified gene . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Duggal, P., Vesely, M. R., Wattanasirichaigoon, D., Villafane, J., Kaushik, V., Beggs, A. H. (1998). Mutation of the Gene for IsK Associated With Both Jervell and Lange-Nielsen and Romano-Ward Forms of Long-QT Syndrome. Circulation 97: 142-146 [Abstract] [Full Text]