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Previous Volume 337:986-994 October 2, 1997 Number 14 Next

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In postindustrial societies, overeating, inactivity, and obesity have emerged as new challenges in public health.^1,2 Considerable effort is now being devoted to determining the pathophysiologic consequences of overeating. Several lines of evidence suggest that caloric intake influences the rate of aging and the onset of associated diseases in animals and, possibly, humans.^3,4,5

The observation that laboratory rats not only live longer but also have fewer age-associated diseases when their food intake is restricted dates back to the 1930s.^3,4,5,6,7 Numerous subsequent studies have found that when the ad libitum food intake of mice and rats was reduced by 30 to 60 . . . [Full Text of this Article]

Caloric Intake, Longevity, and Disease in Laboratory Animals

The Role of Oxidative Stress

Caloric Intake and Health

Discussion

Source Information

From the Department of Medicine and Veterans Affairs Geriatric Research, Education, and Clinical Center, University of Wisconsin, Madison, (R.W.); and the Department of Biological Sciences, Southern Methodist University, Dallas (R.S.S.).

Address reprint requests to Dr. Weindruch at the Veterans Affairs Hospital (GRECC 11G), 2500 Overlook Terr., Madison, WI 53705.

References

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