FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 337:1076-1077 October 9, 1997 Number 15 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Until recently, chemotherapy and hematopoietic stem-cell transplantation were the only therapeutic options in acute leukemia. The idea of restoring normal differentiation in primitive leukemic cells seemed unrealistic until the effect of all-trans-retinoic acid in acute promyelocytic leukemia was shown.

In acute promyelocytic leukemia, which constitutes about 10 percent of the cases of acute myeloid leukemia, there is an accumulation of leukemic blasts carrying a t(15;17) translocation that fuses the promyelocytic leukemia gene (PML) on chromosome 15 to the retinoic acid receptor alpha gene (RAR) on chromosome 17. This chimeric gene encodes the promyelocytic leukemia–retinoic . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Fazi, F., Zardo, G., Gelmetti, V., Travaglini, L., Ciolfi, A., Di Croce, L., Rosa, A., Bozzoni, I., Grignani, F., Lo-Coco, F., Pelicci, P. G., Nervi, C. (2007). Heterochromatic gene repression of the retinoic acid pathway in acute myeloid leukemia. Blood 109: 4432-4440 [Abstract] [Full Text]  
• Osanai, M., Petkovich, M. (2005). Expression of the Retinoic Acid-Metabolizing Enzyme CYP26A1 Limits Programmed Cell Death. Mol. Pharmacol. 67: 1808-1817 [Abstract] [Full Text]  
• Beaumont, M., Sanz, M., Carli, P.M., Maloisel, F., Thomas, X., Detourmignies, L., Guerci, A., Gratecos, N., Rayon, C., San Miguel, J., Odriozola, J., Cahn, J.Y., Huguet, F., Vekhof, A., Stamatoulas, A., Dombret, H., Capote, F., Esteve, J., Stoppa, A.M., Fenaux, P. (2003). Therapy-Related Acute Promyelocytic Leukemia. JCO 21: 2123-2137 [Abstract] [Full Text]  
• Murate, T., Suzuki, M., Hattori, M., Takagi, A., Kojima, T., Tanizawa, T., Asano, H., Hotta, T., Saito, H., Yoshida, S., Tamiya-Koizumi, K. (2002). Up-regulation of Acid Sphingomyelinase during Retinoic Acid-induced Myeloid Differentiation of NB4, a Human Acute Promyelocytic Leukemia Cell Line. J. Biol. Chem. 277: 9936-9943 [Abstract] [Full Text]  
• Ferrara, F. F., Fazi, F., Bianchini, A., Padula, F., Gelmetti, V., Minucci, S., Mancini, M., Pelicci, P. G., Coco, F. L., Nervi, C. (2001). Histone Deacetylase-targeted Treatment Restores Retinoic Acid Signaling and Differentiation in Acute Myeloid Leukemia. Cancer Res. 61: 2-7 [Abstract] [Full Text]  
• Sainty, D., Liso, V., Cantu-Rajnoldi, A., Head, D., Mozziconacci, M.-J., Arnoulet, C., Benattar, L., Fenu, S., Mancini, M., Duchayne, E., Mahon, F.-X., Gutierrez, N., Birg, F., Biondi, A., Grimwade, D., Lafage-Pochitaloff, M., Hagemeijer, A., Flandrin, G. (2000). A new morphologic classification system for acute promyelocytic leukemia distinguishes cases with underlying PLZF/RARA gene rearrangements. Blood 96: 1287-1296 [Abstract] [Full Text]  
• Melnick, A., Licht, J. D. (1999). Deconstructing a Disease: RAR{alpha}, Its Fusion Partners, and Their Roles in the Pathogenesis of Acute Promyelocytic Leukemia. Blood 93: 3167-3215 [Full Text]  
• Nervi, C., Ferrara, F. F., Fanelli, M., Rippo, M. R., Tomassini, B., Ferrucci, P. F., Ruthardt, M., Gelmetti, V., Gambacorti-Passerini, C., Diverio, D., Grignani, F., Pelicci, P. G., Testi, R. (1998). Caspases Mediate Retinoic Acid-Induced Degradation of the Acute Promyelocytic Leukemia PML/RARalpha Fusion Protein. Blood 92: 2244-2251 [Abstract] [Full Text]