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Volume 337:1090-1091 October 9, 1997 Number 15
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Aluminum Toxicity in Preterm Infants

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 by Bishop, N. J.
To the Editor: The observation by Bishop et al. (May 29 issue)1 regarding aluminum contamination of hyperalimentation solutions is interesting, but we would like to point out several limitations of the study design and analysis.

First, toxicity may be a function of serum aluminum concentrations, but these were not measured. The underlying assumption that increased intake leads to increased serum concentrations may not be valid; Koo et al. found no difference in serum aluminum concentrations in preterm neonates with various levels of aluminum intake.2 Increased intake could be offset by an increase in urinary excretion; without measuring the latter, this . . . [Full Text of this Article]

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