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Previous Volume 337:1215-1219 October 23, 1997 Number 17 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Local anesthetics can be administered by local or regional injection to provide anesthesia during surgery. Regional injection of local anesthetics is used for major nerve block and for spinal (subarachnoid) or epidural block. Although local anesthetics are among the most widely used anesthetic agents and have a good record of clinical safety, questions about their toxicity have recently been raised.

The amide local anesthetics (lidocaine, mepivacaine, and bupivacaine) have replaced the esters (e.g., procaine) because of their stability and the fact that they do not cause allergic reactions. Because of its high lipid solubility and high affinity for nonspecific protein-binding . . . [Full Text of this Article]

Pain

Multimodal Analgesia

Preemptive Analgesia

New Techniques

Pulse Oximetry and Capnography

Airway Management

Postoperative Complications

Nausea and Vomiting

Aspiration Pneumonitis

Renal Failure and Hepatic Dysfunction

Source Information

From the Department of Anesthesiology, Yale University School of Medicine, 333 Cedar St., New Haven, CT 06520-8051, where reprint requests should be addressed to Dr. Wiklund.

References

This article has been cited by other articles:

• Bailey, P. L., Lu, J. K., Pace, N. L., Orr, J. A., White, J. L., Hamber, E. A., Slawson, M. H., Crouch, D. J., Rollins, D. E. (2000). Effects of Intrathecal Morphine on the Ventilatory Response to Hypoxia. NEJM 343: 1228-1234 [Abstract] [Full Text]