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Editorial
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Volume 337:1304-1306 October 30, 1997 Number 18
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Limiting Therapy for Limited Childhood Non-Hodgkin's Lymphoma

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During the first half of this century, surgery and radiation were the only effective treatments for cancer, and cure was possible only in patients with localized disease. The introduction of chemotherapy in the late 1940s has had a disappointingly limited effect on overall cancer mortality rates but a dramatic effect on mortality rates for specific cancers. In children with lymphomas, for example, the expectancy of cure is excellent. Several chemotherapy protocols now offer a chance of permanent eradication of the disease in 80 to 90 percent of patients, depending on the histologic subtype.1,2,3,4 This remarkable result has not been achieved . . . [Full Text of this Article]

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