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Correspondence
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Volume 337:1320-1321 October 30, 1997 Number 18
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Granulocyte Colony-Stimulating Factor in Children with Acute Lymphoblastic Leukemia

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 by Pui, C.-H.
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To the Editor: The conclusion of Pui et al. (June 19 issue)1 that "whether the benefits of G-CSF [granulocyte colony-stimulating factor] therapy justify its use in individual cases is ultimately a matter of clinical judgment" is surprising. Their study showed that G-CSF use halved the median duration of hospital stays (from 10 days to 6 days, P = 0.011) and the incidence of documented infections (from 27 to 12, P = 0.009). Children receiving G-CSF had fewer episodes of bacteremia, disseminated fungal infections, cellulitis, central venous catheter–associated infections, otitis media, Clostridium difficile enterocolitis, and lymphadenitis. Nevertheless, the editorial in the . . . [Full Text of this Article]

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