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Volume 337:1322-1324 October 30, 1997 Number 18
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Minocycline for Symptomatic Neurosyphilis in Patients Allergic to Penicillin

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To the Editor: Treatment of symptomatic neurosyphilis is an increasingly common clinical problem because of its rising incidence, particularly in patients coinfected with the human immunodeficiency virus type 1 (HIV-1).1 The mainstay of treatment remains intravenous penicillin G at high dosage, ranging from 12 million to 24 million units given six times a day for 10 to 14 days.1 Treatment options for patients with neurosyphilis who are allergic to penicillin are limited. Such patients should undergo a skin test and hospitalization for a penicillin-desensitization protocol before intravenous penicillin administration.2,3 We know little, however, about the outcomes of high-dose penicillin G . . . [Full Text of this Article]

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