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Previous Volume 337:125-126 July 10, 1997 Number 2 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Bone density is known to have strong genetic determinants. On the basis of studies of twins and mother–daughter pairs, it is estimated that heredity accounts for up to 70 percent of the variance in bone density in both women and men.¹ Thus, the identification of the genes that mediate these heritable effects could lead to a better understanding of the pathogenesis of osteoporosis, a means to identify those at risk for this disease, and more rational ways to prevent and treat it.

One candidate is the gene for the vitamin D receptor, because the vitamin D–endocrine system controls multiple aspects . . . [Full Text of this Article]

References

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• Kawaguchi, Y., Kanamori, M., Ishihara, H., Ohmori, K., Matsui, H., Kimura, T. (2002). The Association of Lumbar Disc Disease with Vitamin-D Receptor Gene Polymorphism. JBJS 84: 2022-2028 [Abstract] [Full Text]  
• Mattano, L. A. Jr, Sather, H. N., Trigg, M. E., Nachman, J. B. (2000). Osteonecrosis as a Complication of Treating Acute Lymphoblastic Leukemia in Children: A Report From the Children's Cancer Group. JCO 18: 3262-3272 [Abstract] [Full Text]  
• Suarez, F., Rossignol, C., Garabédian, M. (1998). Interactive Effect of Estradiol and Vitamin D Receptor Gene Polymorphisms as a Possible Determinant of Growth in Male and Female Infants. J. Clin. Endocrinol. Metab. 83: 3563-3568 [Abstract] [Full Text]