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Previous Volume 337:129-131 July 10, 1997 Number 2 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Packer, M. Related Article by Packer, M. Related Article by The Digitalis Investigation Group PubMed Citation

To the Editor: The report by the Digitalis Investigation Group (Feb. 20 issue)¹ on the effect of digitalis on mortality and morbidity in patients with heart failure raises several questions. The Digitalis Investigation Group chose a strategy of discontinuing digoxin in 44 percent of their patients with chronic heart failure who were treated with diuretics, angiotensin-converting–enzyme (ACE) inhibitors, and digoxin. Therefore, a positive bias toward a favorable effect of digoxin may have been introduced because those patients were treated successfully with digitalis. Concomitantly, Packer et al.² have unequivocally demonstrated that the discontinuation of digoxin is associated with worsening heart failure . . . [Full Text of this Article]

References

This article has been cited by other articles:

• van Veldhuisen, D. J. (2002). Low-dose digoxin in patients with heart failure: Less toxic and at least as effective?. J Am Coll Cardiol 39: 954-956 [Full Text]