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Volume 337:136-137 July 10, 1997 Number 2
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A History of Transplantation Immunology

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By Leslie Brent. 482 pp. San Diego, Calif., Academic Press, 1997. $35. ISBN 0-12-131770-6.

After seeing the burns suffered by a British airman in World War II, Peter Medawar resolved to find a means for inducing immunologic tolerance to allogeneic skin transplants. By 1953 he and his coworkers Rupert Billingham and Leslie Brent had published a landmark paper on the subject, which eventually led to Medawar's sharing the Nobel prize in medicine in 1960. Brent was a graduate student at the time neonatally induced tolerance in mice was first achieved, and it would be hard to imagine a more exciting initiation into the world of medical research. From that beginning there emerged a new . . . [Full Text of this Article]




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