FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 337:1429-1434 November 13, 1997 Number 20 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Most patients with corticotropin-independent Cushing's syndrome have an adrenal adenoma or carcinoma,¹ but a few have bilateral adrenal hyperplasia. Three patients with Cushing's syndrome and corticotropin-independent bilateral adrenal hyperplasia^2,3,4 and two patients with adrenal adenomas^5,6 in whom food stimulated cortisol secretion have been described; the abnormal adrenal tissues in these patients aberrantly overexpressed receptors for gastric inhibitory polypeptide.^6,7 We describe a patient with Cushing's syndrome and corticotropin-independent bilateral adrenal hyperplasia in whom endogenous catecholamines, acting through an ectopic adrenal -adrenergic receptor, stimulated cortisol secretion; the hyperadrenocorticism was inhibited by -blockade.

Case Report

A 56-year-old man presented with a left ileofemoral thrombophlebitis, an . . . [Full Text of this Article]

Methods

Clinical Studies

Assays

-Adrenergic–Receptor Binding and Adenylyl Cyclase Assays

Results

In Vivo Studies

In Vitro Studies

-Adrenergic–Receptor Binding

Adrenal-Membrane Adenylyl Cyclase Activity

Discussion

Source Information

From the Division of Endocrinology and the Department of Medicine, Research Center, Pavillon Hôtel-Dieu, Centre Hospitalier de l'Université de Montréal (A.L., J.T., P.H.), and the Research Group on the Autonomic Nervous System, Department of Biochemistry, Université de Montréal (G.R., M.B.) — both in Montreal.

Address reprint requests to Dr. Lacroix at the Research Center, Pavillon Hôtel-Dieu, CHUM, 3850 St.-Urbain, Montreal, QC H2W 1T8, Canada.

References

This article has been cited by other articles:

• Hsiao, H.-P., Kirschner, L. S., Bourdeau, I., Keil, M. F., Boikos, S. A., Verma, S., Robinson-White, A. J., Nesterova, M., Lacroix, A., Stratakis, C. A. (2009). Clinical and Genetic Heterogeneity, Overlap with Other Tumor Syndromes, and Atypical Glucocorticoid Hormone Secretion in Adrenocorticotropin-Independent Macronodular Adrenal Hyperplasia Compared with Other Adrenocortical Tumors. J. Clin. Endocrinol. Metab. 94: 2930-2937 [Abstract] [Full Text]  
• Lampron, A., Bourdeau, I., Oble, S., Godbout, A., Schurch, W., Arjane, P., Hamet, P., Lacroix, A. (2009). Regulation of Aldosterone Secretion by Several Aberrant Receptors Including for Glucose-Dependent Insulinotropic Peptide in a Patient with an Aldosteronoma. J. Clin. Endocrinol. Metab. 94: 750-756 [Abstract] [Full Text]  
• Zwermann, O, Suttmann, Y, Bidlingmaier, M, Beuschlein, F, Reincke, M (2009). Screening for membrane hormone receptor expression in primary aldosteronism. Eur J Endocrinol 160: 443-451 [Abstract] [Full Text]  
• Vezzosi, D, Cartier, D, Regnier, C, Otal, P, Bennet, A, Parmentier, F, Plantavid, M, Lacroix, A, Lefebvre, H, Caron, P (2007). Familial adrenocorticotropin-independent macronodular adrenal hyperplasia with aberrant serotonin and vasopressin adrenal receptors. Eur J Endocrinol 156: 21-31 [Abstract] [Full Text]  
• Louiset, E., Contesse, V., Groussin, L., Cartier, D., Duparc, C., Barrande, G., Bertherat, J., Vaudry, H., Lefebvre, H. (2006). Expression of Serotonin7 Receptor and Coupling of Ectopic Receptors to Protein Kinase A and Ionic Currents in Adrenocorticotropin-Independent Macronodular Adrenal Hyperplasia Causing Cushing's Syndrome. J. Clin. Endocrinol. Metab. 91: 4578-4586 [Abstract] [Full Text]  
• Swords, F. M., Aylwin, S., Perry, L., Arola, J., Grossman, A. B., Monson, J. P., Clark, A. J. L. (2005). The Aberrant Expression of the Gastric Inhibitory Polypeptide (GIP) Receptor in Adrenal Hyperplasia: Does Chronic Adrenocorticotropin Exposure Stimulate Up-Regulation of GIP Receptors in Cushing's Disease?. J. Clin. Endocrinol. Metab. 90: 3009-3016 [Abstract] [Full Text]  
• Dluhy, R. G., Maher, M. M., Wu, C.-L. (2005). Case 7-2005 - A 59-Year-Old Woman with an Incidentally Discovered Adrenal Nodule. NEJM 352: 1025-1032 [Full Text]  
• Bertherat, J., Contesse, V., Louiset, E., Barrande, G., Duparc, C., Groussin, L., Emy, P., Bertagna, X., Kuhn, J.-M., Vaudry, H., Lefebvre, H. (2005). In Vivo and in Vitro Screening for Illegitimate Receptors in Adrenocorticotropin-Independent Macronodular Adrenal Hyperplasia Causing Cushing's Syndrome: Identification of Two Cases of Gonadotropin/Gastric Inhibitory Polypeptide-Dependent Hypercortisolism. J. Clin. Endocrinol. Metab. 90: 1302-1310 [Abstract] [Full Text]  
• Mannelli, M., Ferruzzi, P., Luciani, P., Crescioli, C., Buci, L., Corona, G., Serio, M., Peri, A. (2003). Cushing's Syndrome in a Patient with Bilateral Macronodular Adrenal Hyperplasia Responding to Cisapride: An in Vivo and in Vitro Study. J. Clin. Endocrinol. Metab. 88: 4616-4622 [Abstract] [Full Text]  
• Fragoso, M. C. B. V., Domenice, S., Latronico, A. C., Martin, R. M., Pereira, M. A. A., Zerbini, M. C. N., Lucon, A. M., Mendonca, B. B. (2003). Cushing's Syndrome Secondary to Adrenocorticotropin-Independent Macronodular Adrenocortical Hyperplasia due to Activating Mutations of GNAS1 Gene. J. Clin. Endocrinol. Metab. 88: 2147-2151 [Abstract] [Full Text]  
• Mune, T., Murase, H., Yamakita, N., Fukuda, T., Murayama, M., Miura, A., Suwa, T., Hanafusa, J., Daido, H., Morita, H., Yasuda, K. (2002). Eutopic Overexpression of Vasopressin V1a Receptor in Adrenocorticotropin-Independent Macronodular Adrenal Hyperplasia. J. Clin. Endocrinol. Metab. 87: 5706-5713 [Abstract] [Full Text]  
• Bourdeau, I., D'Amour, P., Hamet, P., Boutin, J.-M., Lacroix, A. (2001). Aberrant Membrane Hormone Receptors in Incidentally Discovered Bilateral Macronodular Adrenal Hyperplasia with Subclinical Cushing's Syndrome. J. Clin. Endocrinol. Metab. 86: 5534-5540 [Abstract] [Full Text]  
• Hiroi, N., Chrousos, G. P., Kohn, B., Lafferty, A., Abu-Asab, M., Bonat, S., White, A., Bornstein, S. R. (2001). Adrenocortical-Pituitary Hybrid Tumor Causing Cushing's Syndrome. J. Clin. Endocrinol. Metab. 86: 2631-2637 [Abstract] [Full Text]  
• Lacroix, A., N'Diaye, N., Tremblay, J., Hamet, P. (2001). Ectopic and Abnormal Hormone Receptors in Adrenal Cushing's Syndrome. Endocr. Rev. 22: 75-110 [Abstract] [Full Text]  
• Tsagarakis, S., Tsigos, C., Vassiliou, V., Tsiotra, P., Pratsinis, H., Kletsas, D., Trivizas, P., Nikou, A., Mavromatis, T., Sotsiou, F., Raptis, S., Thalassinos, N. (2001). Food-Dependent Androgen and Cortisol Secretion by a Gastric Inhibitory Polypeptide-Receptor Expressive Adrenocortical Adenoma Leading to Hirsutism and Subclinical Cushing's Syndrome: In Vivo and in Vitro Studies. J. Clin. Endocrinol. Metab. 86: 583-589 [Abstract] [Full Text]  
• Mircescu, H., Jilwan, J., N'Diaye, N., Bourdeau, I., Tremblay, J., Hamet, P., Lacroix, A. (2000). Are Ectopic or Abnormal Membrane Hormone Receptors Frequently Present in Adrenal Cushing's Syndrome?. J. Clin. Endocrinol. Metab. 85: 3531-3536 [Abstract] [Full Text]  
• Groussin, L., Massias, J. F., Bertagna, X., Bertherat, J. (2000). Loss of Expression of the Ubiquitous Transcription Factor cAMP Response Element-Binding Protein (CREB) and Compensatory Overexpression of the Activator CREM{tau} in the Human Adrenocortical Cancer Cell Line H295R. J. Clin. Endocrinol. Metab. 85: 345-354 [Abstract] [Full Text]  
• Lacroix, A., Hamet, P., Boutin, J.-M. (1999). Leuprolide Acetate Therapy in Luteinizing Hormone-Dependent Cushing's Syndrome. NEJM 341: 1577-1581 [Full Text]  
• Pralong, F. P., Gomez, F., Guillou, L., Mosimann, F., Franscella, S., Gaillard, R. C. (1999). Food-Dependent Cushing's Syndrome: Possible Involvement of Leptin in Cortisol Hypersecretion. J. Clin. Endocrinol. Metab. 84: 3817-3822 [Abstract] [Full Text]  
• N’Diaye, N., Hamet, P., Tremblay, J., Boutin, J.-M., Gaboury, L., Lacroix, A. (1999). Asynchronous Development of Bilateral Nodular Adrenal Hyperplasia in Gastric Inhibitory Polypeptide-Dependent Cushing's Syndrome. J. Clin. Endocrinol. Metab. 84: 2616-2622 [Abstract] [Full Text]  
• Bornstein, S. R., Stratakis, C. A., Chrousos, G. P. (1999). Adrenocortical Tumors: Recent Advances in Basic Concepts and Clinical Management. ANN INTERN MED 130: 759-771 [Abstract] [Full Text]  
• Stratakis, C. A., Carney, J. A., Kirschner, L. S., S. Willenberg, H., Brauer, S., Ehrhart-Bornstein, M., R. Bornstein, S. (1999). Synaptophysin Immunoreactivity in Primary Pigmented Nodular Adrenocortical Disease: Neuroendocrine Properties of Tumors Associated with Carney Complex. J. Clin. Endocrinol. Metab. 84: 1122-1128 [Abstract] [Full Text]  
• Newell-Price, J., Trainer, P., Besser, M., Grossman, A. (1998). The Diagnosis and Differential Diagnosis of Cushing's Syndrome and Pseudo-Cushing's States. Endocr. Rev. 19: 647-672 [Abstract] [Full Text]  
• Lacroix, A. (1998). Five-Year Experience with Laparoscopic Adrenalectomy at Hotel-Dieu in Montreal: Endocrinologist's Perspective. J. Clin. Endocrinol. Metab. 83: 3043-3046 [Full Text]  
• Chabre, O., Liakos, P., Vivier, J., Chaffanjon, P., Labat-Moleur, F., Martinie, M., Bottari, S. P., Bachelot, I., Chambaz, E. M., Defaye, G., Feige, J.-J. (1998). Cushing's Syndrome due to a Gastric Inhibitory Polypeptide-Dependent Adrenal Adenoma: Insights into Hormonal Control of Adrenocortical Tumorigenesis. J. Clin. Endocrinol. Metab. 83: 3134-3143 [Abstract] [Full Text]  
• N’Diaye, N., Tremblay, J., Hamet, P., De Herder, W. W., Lacroix, A. (1998). Adrenocortical Overexpression of Gastric Inhibitory Polypeptide Receptor Underlies Food-Dependent Cushing's Syndrome. J. Clin. Endocrinol. Metab. 83: 2781-2785 [Abstract] [Full Text]  
• Willenberg, H. S., Stratakis, C. A., Marx, C., Ehrhart-Bornstein, M., Chrousos, G. P., Bornstein, S. R. (1998). Aberrant Interleukin-1 Receptors in a Cortisol-Secreting Adrenal Adenoma Causing Cushing's Syndrome. NEJM 339: 27-31 [Full Text]  
• Arnaldi, G., Gasc, J.-M., de Keyzer, Y., Raffin-Sanson, M.-L., Perraudin, V., Kuhn, J.-M., Raux-Demay, M.-C., Luton, J.-P., Clauser, E., Bertagna, X. (1998). Variable Expression of the V1 Vasopressin Receptor Modulates the Phenotypic Response of Steroid-Secreting Adrenocortical Tumors. J. Clin. Endocrinol. Metab. 83: 2029-2035 [Abstract] [Full Text]  
• Ehrhart-Bornstein, M., Hinson, J. P., Bornstein, S. R., Scherbaum, W. A., Vinson, G. P. (1998). Intraadrenal Interactions in the Regulation of Adrenocortical Steroidogenesis. Endocr. Rev. 19: 101-143 [Abstract] [Full Text]