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Previous Volume 337:1512-1523 November 20, 1997 Number 21 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Vasculitis is inflammation of vessel walls. It has many causes, although they result in only a few histologic patterns of vascular inflammation. Vessels of any type in any organ can be affected, a fact that results in a wide variety of signs and symptoms. These protean clinical manifestations, combined with the etiologic nonspecificity of the histologic lesions, complicate the diagnosis of specific forms of vasculitis. This is problematic because different vasculitides with indistinguishable clinical presentations have very different prognoses and treatments. For example, a patient with purpura, nephritis, and abdominal pain caused by Henoch–Schönlein purpura usually has a good prognosis . . . [Full Text of this Article]

Historical Background

Discovery and Categorization of Necrotizing Arteritis

Historical Description of the Manifestations of Venulitis and Capillaritis

Antineutrophil Cytoplasmic Autoantibodies

Diagnosis and Treatment of Small-Vessel Vasculitis

General Signs and Symptoms of Small-Vessel Vasculitis

Diagnostic Strategy

            Cutaneous Leukocytoclastic Angiitis

            Henoch–Schönlein Purpura

            Cryoglobulinemic Vasculitis

            Anca-Associated Small-Vessel Vasculitis

Recommendations

Source Information

From the Departments of Pathology and Laboratory Medicine (J.C.J.) and Medicine (R.J.F.), University of North Carolina at Chapel Hill, Chapel Hill.

Address reprint requests to Dr. Jennette at CB#7525, Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599-7525.

References

Related Letters:

Small-Vessel Vasculitis
Matteson E. L., Jennette J. C., Falk R. J.
Extract | Full Text  
N Engl J Med 1998; 338:994-995, Apr 2, 1998. Correspondence

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