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Previous Volume 337:1604-1611 November 27, 1997 Number 22 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Multiple sclerosis is a common disease of the central nervous system affecting approximately 1 million young adults, mostly women, worldwide.¹ It is characterized by episodic neurologic symptoms that are often followed by fixed neurologic deficits, increasing disability, and medical, socioeconomic, and physical decline over a period of 30 to 40 years.

For most of the 20th century, multiple sclerosis was considered untreatable. In 1982, the Multiple Sclerosis Society of Canada and the National Multiple Sclerosis Society of the United States sponsored the first international workshop on therapeutic trials.² This workshop served to usher in an era of activism and optimism . . . [Full Text of this Article]

Disease Characteristics Related to Treatment Decisions

Design of Clinical Trials

Relation between Treatment Strategies and Pathogenesis

Controlled Clinical Trials

Relapsing Multiple Sclerosis

Corticosteroids

Interferon Beta

Glatiramer Acetate

Azathioprine

Intravenous Immune Globulin

Progressive Multiple Sclerosis

Methotrexate

Cyclophosphamide

Cyclosporine

Future Directions

Source Information

From the Mellen Center for Multiple Sclerosis Treatment and Research, Department of Neurology, Cleveland Clinic Foundation, Cleveland, OH 44106, where reprint requests should be addressed to Dr. Rudick.

References

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