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Previous Volume 337:1623-1625 November 27, 1997 Number 22 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The enduring puzzle of sickle cell anemia is how a single deviant base in DNA, which changes a single amino acid in a single protein within a single type of cell, causes a disease with such variable clinical manifestations. Clearly, additional factors — situational and genetic — influence the course of this genetically simple yet clinically complex disorder. Genetic variables that influence the severity of sickle cell disease include levels of other hemoglobins, such as hemoglobin F or hemoglobin C. Other factors, such as responses to episodes of infectious disease, are strongly suspected to predispose patients to sickle crises, but . . . [Full Text of this Article]

References

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