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Correspondence
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Volume 337:1631-1633 November 27, 1997 Number 22
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Plasma Homocysteine Levels and Mortality in Patients with Coronary Artery Disease

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 by Nygård, O.
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To the Editor: Nygård et al. (July 24 issue)1 nicely demonstrate an association between elevated plasma homocysteine levels and increased mortality in patients with angiographically confirmed coronary artery disease. It is important to mention that fasting plasma homocysteine levels, as used in this study, identify only some of the patients with disturbances in homocysteine metabolism. Approximately twice as many patients are identified with the additional use of a methionine-loading test.2,3 One could speculate that the effect seen by Nygård et al. would have been even more pronounced if the patients had been further characterized with a methionine-loading test. Homocysteine may . . . [Full Text of this Article]

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