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Correspondence
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Volume 337:1697-1698 December 4, 1997 Number 23
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Treatment of Early Syphilis

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 by Rolfs, R. T.
To the Editor: Rolfs and coworkers (July 31 issue)1 convincingly demonstrated that Treponema pallidum invades the central nervous system in at least one fourth of persons with early syphilis regardless of their status with respect to human immunodeficiency virus (HIV) infection. In addition, they adequately demonstrated that serologically defined treatment failure did not reflect early clinically defined treatment failure. Their study did not, however, address the long-term neurologic sequelae, which usually take from 15 to 25 years to occur.2 The purpose of using a treatment regimen such as amoxicillin and probenecid is not to increase the likelihood that acute symptoms . . . [Full Text of this Article]

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