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Correspondence
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Volume 337:1849-1850 December 18, 1997 Number 25
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Increased Serum Prostate-Specific Antigen in a Man and a Woman with Hepatitis A

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To the Editor: Although prostate-specific antigen (PSA) was originally thought to be a prostate-epithelium–specific marker,1 it has now been described in other tissues and body fluids, including liver, colon, lung, kidney, breast, ovarian, and parotid tumors; normal breast; salivary gland and endometrium; breast milk; and amniotic fluid.2,3,4 Likewise, the prostate-specific membrane antigen is a novel biomarker that can be detected in a variety of healthy and malignant non-prostate tissues.3,5 A quantitative assessment of the tissue expression of this glycoprotein seems to indicate that high levels of prostate-specific membrane antigen transcripts are present in normal liver, brain, and small intestine and . . . [Full Text of this Article]

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