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Previous Volume 337:1914-1915 December 25, 1997 Number 26 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The value of platelet transfusions for thrombocytopenia was first reported in 1910, when Duke described three patients with bleeding due to thrombocytopenia, each of whom showed improvement with transfusions of platelet-containing fresh, whole blood.¹ This discovery was followed by the development of techniques to prepare platelet components, and platelet transfusions were shown to reduce the risk of death from hemorrhage substantially during chemotherapy for leukemia. The current reliance on platelet transfusions is reflected by the fact that in the United States there has been an increase in such transfusions of 5 to 7 percent annually since 1987, even as red-cell . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Kaushansky, K. (2008). Historical review: megakaryopoiesis and thrombopoiesis. Blood 111: 981-986 [Abstract] [Full Text]  
• Millichap, J. G. (2001). Safety of Lumbar Puncture In Children With Leukemia and Thrombocytopenia. AAP Grand Rounds 5: 23-24 [Full Text]  
• Howard, S. C., Gajjar, A., Ribeiro, R. C., Rivera, G. K., Rubnitz, J. E., Sandlund, J. T., Harrison, P. L., de Armendi, A., Dahl, G. V., Pui, C.-H. (2000). Safety of Lumbar Puncture for Children With Acute Lymphoblastic Leukemia and Thrombocytopenia. JAMA 284: 2222-2224 [Abstract] [Full Text]  
• DREWS, R. E., WEINBERGER, S. E. (2000). Thrombocytopenic Disorders in Critically Ill Patients. Am. J. Respir. Crit. Care Med. 162: 347-351 [Full Text]  
• Gratwohl, A., Tichelli, A., Atkins, C. D., Rebulla, P., Marangoni, F., Sirchia, G., Slichter, S. J., Schiffer, C. A., Davis, K. A.B., The Trial to Reduce Alloimmunization to Platelets, (1998). Prophylactic Platelet Transfusions in Acute Myeloid Leukemia. NEJM 338: 1468-1470 [Full Text]  
• (1997). TOWARD MORE EFFECTIVE TRANSFUSION OF PLATELETS. JWatch General 1997: 6-6 [Full Text]