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Previous Volume 337:176-183 July 17, 1997 Number 3 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The difference in amino acid composition between beef and porcine insulins and human insulin was long thought to be responsible for the immunogenicity of these animal insulins in humans. As a result, much of the effort expended to meet the world's increasing demand for insulin was devoted to the development of synthetic human insulin. However, the introduction of highly purified synthetic human insulin in the early 1980s did not entirely solve the problem of immunogenicity, and the new technology was used instead to change the amino acid structure of human insulin to make it more suitable for subcutaneous administration. This . . . [Full Text of this Article]

The Imperfections of Intensive Insulin Therapy

Development of Insulin Analogues

Structure of Insulin Lispro

Biologic Actions of Insulin Lispro

Pharmacokinetics of Insulin Lispro

Clinical Studies of Insulin Lispro

Awareness of Hypoglycemia

Quality of Life

Safety and Immunogenicity

Guidelines for the Use of Insulin Lispro

Future Prospects

Conclusions

Source Information

From the Department of Internal Medicine, Diakonessenhuis, Bosboomstraat 1, 3582 KE Utrecht, the Netherlands, where reprint requests should be addressed to Dr. Holleman.

References

Related Letters:

Possible Adverse Fetal Effect of Insulin Lispro
Diamond T., Kormas N., Anderson J. H., Bastyr E. J., Wishner K. L.
Extract | Full Text  
N Engl J Med 1997; 337:1009-1010, Oct 2, 1997. Correspondence

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