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Previous Volume 337:202 July 17, 1997 Number 3 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The occurrence of multiple organ-specific autoimmune disorders in the same patient has been well recognized.¹ Because of improved assays for adrenal autoantibodies, we recently instituted routine testing of patients with insulin-dependent diabetes mellitus (IDDM) for antibodies against 21-hydroxylase, using the radioassay described by Falorni and coworkers.²

In 11 of 629 patients with IDDM (age, 11 to 40 years) but none of 239 normal subjects, serum samples were positive for 21-hydroxylase antibodies. Among the 11 patients with positive tests, 2 brothers were found to have adrenal insufficiency and 1 patient was antibody-positive at the time of the initial . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Elbelt, U., Hahner, S., Allolio, B. (2009). Altered insulin requirement in patients with type 1 diabetes and primary adrenal insufficiency receiving standard glucocorticoid replacement therapy. Eur J Endocrinol 160: 919-924 [Abstract] [Full Text]  
• Betterle, C., Dal Pra, C., Mantero, F., Zanchetta, R. (2002). Autoimmune Adrenal Insufficiency and Autoimmune Polyendocrine Syndromes: Autoantibodies, Autoantigens, and Their Applicability in Diagnosis and Disease Prediction. Endocr. Rev. 23: 327-364 [Abstract] [Full Text]  
• Morse, J. H. (2002). Bone Morphogenetic Protein Receptor 2 Mutations in Pulmonary Hypertension. Chest 121 : 50S-53S [Abstract] [Full Text]  
• Thomson, J R, Trembath, R C (2000). Primary pulmonary hypertension: the pressure rises for a gene. J. Clin. Pathol. 53: 899-903 [Abstract] [Full Text]  
• Morse, J. H, Horn, E. M, Barst, R. J (1999). Hormone Replacement Therapy : A Possible Risk Factor in Carriers of Familial Primary Pulmonary Hypertension. Chest 116: 847-847 [Full Text]  
• Yu, L., Brewer, K. W., Gates, S., Wu, A., Wang, T., Babu, S. R., Gottlieb, P. A., Freed, B. M., Noble, J., Erlich, H. A., Rewers, M. J., Eisenbarth, G. S. (1999). DRB104 and DQ Alleles: Expression of 21-Hydroxylase Autoantibodies and Risk of Progression to Addison's Disease. J. Clin. Endocrinol. Metab. 84: 328-335 [Abstract] [Full Text]  
• Laureti, S., De Bellis, A., Muccitelli, V. I., Calcinaro, F., Bizzarro, A., Rossi, R., Bellastella, A., Santeusanio, F., Falorni, A. (1998). Levels of Adrenocortical Autoantibodies Correlate with the Degree of Adrenal Dysfunction in Subjects with Preclinical Addison's Disease. J. Clin. Endocrinol. Metab. 83: 3507-3511 [Abstract] [Full Text]