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Correspondence
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Volume 337:204 July 17, 1997 Number 3
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Predispositions to Meningococcemia

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 by Gomez, R.
To the Editor: The Image in Clinical Medicine titled ``Meningococcemia'' (March 6 issue)1 was accompanied by a brief case history and showed the peripheral-blood smear of a 14-year-old boy with meningococcemia. The diagnosis of systemic lupus erythematosus in a young male patient should, however, alert physicians to the possibility of an underlying complement-factor deficiency, particularly of the early-acting factors (autosomal recessive). In addition, the diagnosis of meningococcemia should encourage the investigation of a properdin (sex-linked) factor-D (autosomal recessive) or late-acting complement-factor deficiency (C5-C9, autosomal recessive). It is therefore extremely important that the patient's siblings be checked for such deficiencies in . . . [Full Text of this Article]

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