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Previous Volume 337:280-281 July 24, 1997 Number 4 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Moreno et al. (March 20 issue)¹ describe a mild form of idiopathic biliary intrahepatic ductopenia in 24 asymptomatic adults who had persistently abnormal results on liver-function tests for at least one year. The authors state that liver injury from drugs or toxic agents was ruled out after comprehensive and careful interviews with the patients. The histopathological features shown, however, raise the question of long-term drug use. Pericanalicular lipofuscinosis is reported in all the patients, with ground-glass hepatocytes in 18. These findings are characteristic and highly suggestive of the long-term use of medications metabolized by hepatocytes.² Ground-glass hepatocytes . . . [Full Text of this Article]

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