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Editorial
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Volume 337:339-341 July 31, 1997 Number 5
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Prostate Cancer — The Therapeutic Challenge of Locally Advanced Disease

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The treatment of localized prostate cancer is a matter of considerable controversy. For decades experts vigorously debated the relative merits of radical prostatectomy and external-beam radiotherapy. During those years the proportion of patients who received radiotherapy remained high, because of the complications of surgery and the older age of the patients, and because most physicians believed that external-beam radiotherapy was the only cure for disease that had spread outside the prostate (i.e., stage T3 or T4).

In the past decade, however, the proportion of patients treated with radiation changed dramatically. Because of the widespread use of prostate-specific-antigen (PSA) testing for . . . [Full Text of this Article]

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