Edited by Leon Poller and Jack Hirsh. 280 pp., illustrated. London, Arnold, 1996. (Distributed by Oxford University Press, New York.) $125. ISBN 0-340-55266-2.
Venous thromboembolism and arterial thromboembolism are leadingcauses of morbidity and mortality in the developed countries.During the past two decades, there has been substantial progressin understanding the mechanisms of thromboembolism, in clinicalmanagement, and in prophylaxis. Oral anticoagulants have beenused for more than 50 years, but their role in treating andpreventing thromboembolism has recently been greatly expanded.There are two reasons for this: excellent randomized clinicaltrials that have shown the efficacy of these drugs in, for example,reducing the risk of stroke in patients with atrial fibrillation,and the development of standardized methods to measure . . . [Full Text of this Article]
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