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Correspondence
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Volume 337:502-503 August 14, 1997 Number 7
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Melanoma after PUVA Therapy for Psoriasis

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by Stern, R. S.
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To the Editor: The report by Stern et al. (April 10 issue)1 of a cohort of 1380 patients with psoriasis who were treated with oral methoxsalen (psoralen) and ultraviolet A radiation (PUVA) suggests that PUVA therapy is associated with a higher incidence of melanoma than expected, but this finding may be due to inaccurate statistics on melanoma, confounding variables, and surveillance bias.

Their estimate of relative risk compared the observed number of melanomas in the PUVA cohort over a 20-year period with the expected number, based on cancer statistics from the Surveillance, Epidemiology, and End Results (SEER) data. These data . . . [Full Text of this Article]

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