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Previous Volume 337:504 August 14, 1997 Number 7 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Edited by Ernest N. Charlesworth. 363 pp., illustrated. Cambridge, Mass., Blackwell Science, 1996. $150. ISBN 0-86542-370-9.

The skin has a love–hate relationship with T cells. Usually, the liaison works well, protecting the body's outer sheath from invading organisms and incipient cancers. When it sours, the range of destructive autoreactive, inflammatory, and allergic disorders is daunting.

As the interface between our internal and external environments, the integument is constantly challenged by a wide range of insults, from physical injury to invasion by infectious agents. The capacity for rapid mobilization of armies of defensive T lymphocytes to sites of cutaneous injury, presumably a prerequisite for mammalian evolution, depends on elaborate homing mechanisms that bring T cells into the . . . [Full Text of this Article]

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