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A correction has been published: N Engl J Med 1997;337(20):1483.

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Volume 337:602-606 August 28, 1997 Number 9
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Fatal Pulmonary Hypertension Associated with Short-Term Use of Fenfluramine and Phentermine
Eugene J. Mark, M.D., Eva D. Patalas, M.D., Howard T. Chang, M.D., Ph.D., Richard J. Evans, M.D., and Stanton C. Kessler, M.D.

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The dangers inherent in marked obesity have prompted physicians to advocate more aggressive strategies for weight reduction. One current strategy is the prescription of fenfluramine,1,2 either alone or in combination with phentermine, with the knowledge that the risks of the drugs must be balanced against the risks of continued obesity.

Pulmonary hypertension in adults has several causes that can be identified pathologically. In the case of pulmonary hypertension that develops with hypoxia during the course of chronic obstructive or interstitial fibrosing disease of the lung, the pulmonary vessels are characterized by intimal and medial hyperplasia and luminal stenosis. Thromboembolic pulmonary . . . [Full Text of this Article]

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From the Department of Pathology, Massachusetts General Hospital, and Harvard Medical School (E.J.M., H.T.C.), and the Office of the Chief Medical Examiner, Commonwealth of Massachusetts (E.J.M., E.D.P., R.J.E., S.C.K.) — all in Boston.

Address reprint requests to Dr. Mark at the Department of Pathology, Massachusetts General Hospital, 55 Fruit St., Warren Bldg. 219, Boston, MA 02114-2696.

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