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Previous Volume 338:59-62 January 1, 1998 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: We were pleased to see that using an independent protocol, LeLorier et al. (Aug. 21 issue)¹ confirmed both our² previous estimates of the frequency of discrepancies between large trials and meta-analyses and those of Villar et al.³ Their selection of 12 large trials from four influential journals may have inflated the frequency of apparent discrepancies. Such journals may tend to publish trials that are likely to change practice, whose results disagree with prior evidence.⁴ Still, the estimates of LeLorier et al. are largely similar to prior estimates. However, we are concerned that several of their premises propagate . . . [Full Text of this Article]

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