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Previous Volume 338:770-771 March 12, 1998 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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By Jerome J. Platt. 458 pp. Cambridge, Mass., Harvard University Press, 1997. $49.95. ISBN 0-674-13632-2.

Over a century ago, the active ingredient in the coca leaf was purified, and the first cases of cocaine dependence were described in North America and Western Europe. Overlooked for many years, cocaine resurfaced as a public health problem in the 1980s. Today, among the major addictions, cocaine dependence remains the most elusive. Alcohol, opiates, and nicotine all produce characteristic withdrawal syndromes, which respond to treatment with pharmacologic agonists or sympatholytic agents. For cocaine, the withdrawal syndrome is more evanescent, and its treatment implications remain unclear. For alcohol, opiate, and nicotine dependence, a growing list of medications is available to . . . [Full Text of this Article]

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