FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 338:834-835 March 19, 1998 Number 12 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

In response to the controversy over placebo-controlled trials in developing countries of treatments to prevent mother-to-child transmission of the human immunodeficiency virus (HIV),¹ I would like to offer the perspective of someone who lives and works in Thailand, a developing country with limited resources that is the site of several such trials.

Placebo-Controlled Trials in Developing Countries

I believe that placebo-controlled trials are sometimes justified in countries where treatment is otherwise totally unavailable, because at least half the patients (those receiving active treatment) will probably benefit. This is particularly true if the trial will generate results that will directly benefit the patient population under study. . . . [Full Text of this Article]

Approval of Placebo-Controlled Trials in Thailand

Changing Circumstances

Unethical Studies in Developing Countries

Source Information

Thai Red Cross Society
Bangkok 10330, Thailand

Address reprint requests to Dr. Phanuphak at the Program on AIDS, Thai Red Cross Society, 1871 Rama IV Rd., Bangkok 10330, Thailand.

References

Related Letters:

Studies in Thailand of the Vertical Transmission of HIV
Robb M. L., Khambaroong C., Nelson K. E., Wongchoosri S., Wera-arpachai M., Gulgolgarn V., Ketsararat W., Sittisombut N., Tovanabutra S.
Extract | Full Text  
N Engl J Med 1998; 338:843-844, Mar 19, 1998. Correspondence

This article has been cited by other articles:

• Hyder, A A, Wali, S A, Khan, A N, Teoh, N B, Kass, N E, Dawson, L (2004). Ethical review of health research: a perspective from developing country researchers. J. Med. Ethics 30: 68-72 [Abstract] [Full Text]  
• Preston, R. A., Materson, B. J., Reda, D. J., Williams, D. W. (2000). Placebo-Associated Blood Pressure Response and Adverse Effects in the Treatment of Hypertension: Observations From a Department of Veterans Affairs Cooperative Study. Arch Intern Med 160: 1449-1454 [Abstract] [Full Text]  
• Merson, M. H., Simonds, R.J., Rogers, M. F., Dondero, T. J., Francis, D. P., Mbidde, E. K., Blanche, S., Kim, R. J., Sharif, S. K., Tafesse, E., Murphy, T. F., IJsselmuiden, C. B., Herrington, D., Piot, P., Glantz, L. H., Grodin, M. A., Lallemant, M., McIntosh, K., Jourdain, G., Le Coeur, S., Vithayasai, V., Lee, T.-H., Hammer, S., Prescott, N., Essex, M., Lurie, P., Wolfe, S. M. (1998). Ethics of Placebo-Controlled Trials of Zidovudine to Prevent the Perinatal Transmission of HIV in the Third World. NEJM 338: 836-841 [Full Text]  
• Robb, M. L., Khambaroong, C., Nelson, K. E., Wongchoosri, S., Wera-arpachai, M., Gulgolgarn, V., Ketsararat, W., Sittisombut, N., Tovanabutra, S. (1998). Studies in Thailand of the Vertical Transmission of HIV. NEJM 338: 843-844 [Full Text]