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Correspondence
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Volume 338:836-841 March 19, 1998 Number 12
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Ethics of Placebo-Controlled Trials of Zidovudine to Prevent the Perinatal Transmission of HIV in the Third World

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 by Lurie, P.
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 by Varmus, H.
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To the Editor: Lurie and Wolfe (Sept. 18 issue)1 claim that ongoing placebo-controlled trials of antiretroviral agents to reduce perinatal transmission of the human immunodeficiency virus (HIV) in developing countries are unethical. As executive director of the World Health Organization Global Program on AIDS, I convened the June 1994 meeting that considered how best to apply the impressive results of AIDS Clinical Trials Group (ACTG) study 076 in developing countries, where 90 percent of HIV infections occur. Twenty-eight experts from eight developed and six developing countries participated.

Contrary to the accusations of Lurie and Wolfe, the only relevant information known . . . [Full Text of this Article]

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