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Previous Volume 338:910-912 March 26, 1998 Number 13 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Monzon, J. PubMed Citation

In this issue of the Journal, Monzon et al. report the occurrence of germ-line mutations of the CDKN2A gene in patients with multiple primary melanomas.¹ CDKN2A, a tumor-suppressor gene, has a central role in regulating cell division.

The loss of function of tumor-suppressor genes is a key event in the multistep process that transforms a normal cell into a cancer cell. In normal cells, the proteins that arise from these genes participate in diverse biologic processes. Some proteins, such as the p53 protein, protect the cell from genetic damage, and their loss leads to the characteristic genomic instability and . . . [Full Text of this Article]

References

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• Faderl, S., Kantarjian, H. M., Manshouri, T., Chan, C.-Y., Pierce, S., Hays, K. J., Cortes, J., Thomas, D., Estrov, Z., Albitar, M. (1999). The Prognostic Significance of p16INK4a/p14ARF and p15INK4b Deletions in Adult Acute Lymphoblastic Leukemia. Clin. Cancer Res. 5: 1855-1861 [Abstract] [Full Text]  
• Mitra, J., Dai, C. Y., Somasundaram, K., El-Deiry, W. S., Satyamoorthy, K., Herlyn, M., Enders, G. H. (1999). Induction of p21WAF1/CIP1 and Inhibition of Cdk2 Mediated by the Tumor Suppressor p16INK4a. Mol. Cell. Biol. 19: 3916-3928 [Abstract] [Full Text]