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Previous Volume 338:921-922 March 26, 1998 Number 13 Next

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To the Editor: The November 6 issue of the Journal contained two articles^1,2 and an editorial³ that highlighted the complex relation between human papillomaviruses (HPVs), human immunodeficiency virus (HIV), and anogenital cancer. As Frisch et al.² noted, the strong epidemiologic association between sexual behavior, HPVs, and cervical neoplasia has been recognized for some time, and as Dr. Shah adds in the editorial,³ a similar link with anal cancer had been suggested from other studies as well. Although the link between sexual behavior, HPV infection, and anogenital cancer is strong, there are clearly other factors of equal or greater importance, because . . . [Full Text of this Article]

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