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Correspondence
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Volume 338:988-991 April 2, 1998 Number 14
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Organochlorine Residues and Breast Cancer

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 by Safe, S. H.
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 by Hunter, D. J.
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To the Editor: Hunter et al. (Oct. 30 issue)1 report that there is no significant correlation between breast cancer and plasma levels of 1,1'-dichloro-2,2-bis( p-chlorophenyl)ethylene (p,p'-DDE) and polychlorinated biphenyls (PCBs) two to three years before diagnosis, but estrogenic chemicals in pesticides, plastics, and other products that could contribute significantly to the burden of environmental estrogens in the body were not examined. Hunter et al. state, "The blood levels of DDE and PCBs we measured reflect exposure that occurred over a period of many years." Although parent 2,2-bis( p-chlorophenyl )-1,1,1-trichloroethane (DDT) and PCB mixtures show estrogenic activity, persistent residues . . . [Full Text of this Article]

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